College of Sciences

The Genomic Enumeration of Antibiotic Resistance in Space (GEARS) experiment, managed by NASA's Ames Research Center in California's Silicon Valley, is designed to analyze microbial resistance in space. As part of the study, astronauts collect samples from interior surfaces aboard the ISS to detect antibiotic-resistant bacteria, particularly Enterococcus faecalis, a microorganism naturally found in the human body. This initiative marks the initial phase of broader research on microbial behavior in space and its implications for medicine on Earth.

"Enterococcus is an ancient organism that has coexisted with humans since our evolutionary origins," explained Christopher Carr, co-principal investigator of GEARS and assistant professor in the School of Earth and Atmospheric Sciences and the School of Aerospace Engineering. "It thrives inside and outside its host, contributing to its status as the second leading cause of hospital-acquired infections. Our goal is to understand how this microbe adapts to space conditions."

GEARS aims to refine methods for detecting and identifying resistant bacteria, expanding upon ongoing microbial monitoring efforts aboard the ISS.

Mustard gas, or sulfur mustard, is one of the most harmful chemical warfare agents, causing severe blistering of the skin and mucous membranes upon contact. To enhance battlefield detection of this hazardous substance, a team of chemists, including M.G. Finn, professor in the School of Chemistry and Biochemistry and the School of Biological Sciences, will develop a streamlined method for detecting vesicants—a broader class of chemical agents that includes sulfur mustard.

“We will initially focus on model compounds that act like mustards, but that can be handled safely in the laboratory. This will allow us to test different molecular sensor designs, with Professor Jennifer Heemstra's lab and ours working together on complementary approaches,” Finn explains.